ISSN 2326-7267
International Journal of Pharmacy and Pharmacology ISSN: 2326-7267 Vol. 9 (8), pp. 001-009, August, 2020. © International Scholars Journals
Full Length Research Paper
Comparative study between effect of angiotensin converting enzyme inhibitors and angiotensin receptor blockers on acetic acid- induced ulcerative colitis in rats
Azza H. El-Medany1, Aida A. Guemei2, Hanan H. Hagar3, Jamila H.El-Medany4, Azza M Baraka5,
1/3Department of Pharmacology, College of Medicine at King Khalid University Hospital, King Saudi University, Riyadh, Saudi Arabia
4Department of Anatomy, College of Medicine at King Khalid University Hospital, King Saudi University, Riyadh, Saudi Arabia
2/5Department of Clinical Pharmacology, Faculty of Medicine-Alexandria University-Alexandria-Egypt
Accepted 29 June, 2020
Abstract
Accumulating data suggest the involvement of renin angiotensin system (RAS) in the pathogenesis of inflammatory bowel disease. The aim of the present study was to evaluate the potential protective and therapeutic effects of captopril and valsartan on acetic acid induced- ulcerative colitis in rats. The results were assessed by macroscopic and microscopic examinations of colonic tissues as ell as by biochemical measurement of malondialdehyde (MDA), tumor necrosis factor alpha (TNF-α), transforming growth factor- beta1 (TGF-β1), angiotensin converting enzyme (ACE), reduced glutathione (GSH) and platelet activating factor (PAF) levels in colonic tissues. Oral treatment with captopril or valsartan in a dose of 30 mg kg-1 body weight, starting one day before induction of colitis and continuing for 1 week (prophylactic groups) or starting one week after induction of colitis and continuing for another one week (therapeutic groups), significantly reduced MDA, TNF-α, PAF, TGF-β1 and significantly increased colonic GSH in colonic tissues as compared to acetic acid control groups. Captopril and valsartan attenuated the macroscopic and microscopic colonic damage induced by acetic acid. No significant difference between the effect of either drug could be detected other than the significant decrease in ACE activity in colonic tissue exerted by captopril and not by valsartan, These results suggest that either captopril or valsartan may be effective in prophylaxis as well as in treatment of ulcerative colitis through targeting RAS.
Keywords: Ulcerative colitis, captopril, valsartan, angiotensin converting enzyme, reduced glutathione, tumor necrosis factor alpha, transforming growth factor beta.