ISSN 2326-7267
International Journal of Pharmacy and Pharmacology ISSN: 2326-7267 Vol. 3 (6), pp. 001-009, June, 2012. © International Scholars Journals
Review
Possible benefits of micronutrient supplementation in the treatment and management of HIV infection and AIDS
O. O. Oguntibeju*, A. J. Esterhuyse and E. J. Truter
Oxidative Stress Research Unit, Department of Biomedical Sciences, Faculty of Health and Wellness Sciences, Cape Peninsula University of Technology, Bellville, South Africa.
Accepted 22 March, 2012
Abstract
Recently, several reports have indicated that individuals living with HIV/AIDS undergo a condition of chronic oxidative stress with a resultant decline in nutritional antioxidants and other micronutrients. It has also been reported that these micronutrient deficiencies interfere with immune functions, weaken epithelial integrity, contribute to oxidative stress and enhance HIV disease progression. Reports from observational studies have led to an increasing interest in the possible benefits of micronutrient supplementation as a cost-effective strategy for improving oxidative and nutritional status. Micronutrient supplementation may also assist in the possible prevention of vertical transmission of HIV from mother to child especially in low -income countries where antiretroviral therapy and prophylactic drugs are not readily available. However, there are conflicting reports from other observational studies as to the usefulness or benefits of micronutrient supplementation in the treatment and management of HIV/AIDS. In this review we examine possible benefits of micronutrient supplementation in the treatment and management of HIV infection and AIDS.
Key words: Vitamins, antioxidants, micronutrients, supplementation, HIV infection, AIDS.