ISSN 2326-7267
International Journal of Pharmacy and Pharmacology ISSN: 2326-7267 Vol. 2 (1), pp. 001-007, January, 2011. © International Scholars Journals
Full Length Research Paper
Performance of starch obtained from Dioscorea dumetorium as disintegrant in sodium salicylate tablets
Ibezim, Emmanuel C.1, Ofoefule, Sabinus I2, Omeje, Edwin O3* and Odo, U. E.4
1Department of Pharmaceutics, University of Nigeria, Nsukka, Nigeria.
2Department of Pharmaceutical, Technology and industrial Pharmacy, University of Nigeria, Nsukka, Nigeria.
3Department of Pharmaceutical and Medicinal Chemistry, University of Nigeria, Nsukka, Nigeria.
4Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Nigeria.
Accepted 11 November, 2010
Abstract
Starch obtained from Dioscorea dumetorium was employed as a disintegrant in Sodium Salicylate based tablets at concentrations of 5 –15 %w/w. Properties of the starch evaluated include: bulk and tapped densities, water uptake by capillarity, Hausner’s quotient and percent compressibility. Compound tablets were evaluated for hardness, friability, disintegration time and dissolution rate. Batches of tablets containing equivalent concentrations of AC-di-sol or maize starch were employed as standards. Results obtained indicate that Dioscorea dumetorium starch performed as much better as a disintegrant in sodium salicylate tablets as maize starch but less than Ac-di-sol.
Key words: Disintegrant, starch, Dioscorea dumetorium, sodium salicylate.