ISSN 2326-7267
International Journal of Pharmacy and Pharmacology ISSN: 2326-7267 Vol. 9 (9), pp. 001-016, September, 2020. © International Scholars Journals
Full Length Research Paper
Synthesis, characterization and antimicrobial activity of mixed ligand complexes of Co (II) and Cu (II) with N, O/S donor ligands and amino acids
Alka Choudharya, Renu Sharmaa, Meena Nagara*
aDepartment of Chemistry, University of Rajasthan, Jaipur-302004, India
Accepted 20 September, 2020
Abstract
A series of new mixed ligand complexes of Co(II) and Cu(II) with thiosemicarbazones/semicarbazone {(±)-5-isopropenyl-2-methylcyclohex-2-enthiosemicarbazone (IPMCHTSC, L1H), 1,7,7-trimethylbicyclo[2,2,1]heptanethiosemicarbazone (TBHTSC, L2H) and 1,7,7-trimethylbicyclo [2,2,1]heptanesemicarbazone (TBHSC, L3H)} and amino acids {glycine (A1H) or DL-alanine (A2H)} have been synthesized by the reaction of metal dichloride with ligands IPMCHTSC, TBHSC or TBHTSC and A1H or A2H in a 1:1:1 molar ratio in refluxing ethanol. The newly synthesized complexes (1-12) have been characterized by elemental analyses, molar conductance, electronic, IR, FAB mass spectroscopy and thermogravimetric analysis. On the basis of these spectral data, a square pyramidal geometry was proposed for all of these complexes. FAB mass spectroscopic studies of (1), (3) nd (4) suggest their monomeric nature. The ligands and their complexes have been screened for their antibacterial and antifungal activities against bacterial strains E. coli, S. aureus, P. vulgaris and fungal strains A. niger and C. albicans. The results of these studies show the metal (II) complexes to be more antibacterial/ antifungal against one or more species as compared to the uncomplexed ligands.
Keywords: Thiosemicarbazone, semicarbazone, amino acid, FAB mass, thermogravimetric analysis, antimicrobial activity.