International Journal of Animal Breeding and Genetics

International Journal of Animal Breeding and Genetics Vol. 8 (7), pp. 001-005, July, 2019. © International Scholars Journals

Full Length Research Paper

Biochemical effectiveness in liver detoxication of fresh pineapple (Ananas comosus ) with the wistar rats, previously intoxicated by Doliprane®

Dougnon T*. Jacques, Kpodekon T. Marc and Adjagba Marius

Research Laboratory of Appliqued Biology (LARBA), University of Abomey-Calavi (UAC), 01 Box 2009 Cotonou, Bénin.

Accepted 28 January 2019


The effect of hepatic detoxication with the help of fresh pineapple (Ananas comosus), was evaluated on 28 wistar albinos rats previously intoxicated by DOLIPRANE® containing 20% of paracetamol. Four batches consisting, each them of 7 animals were formed. Batch n° 1, was neither intoxicated nor treated. Batch n° 2 was intoxicated for 2 weeks at the rate of two two (2) grams of DOLIPRANE® per kilogramme of live weight per day, then treated for 4 weeks with 13 mg of fresh pineapple per kg of live weight per day. Batch n°3 was intoxicated in the same way as batch n°2, but received 26 mg of fresh pineapple during 4 weeks. Batch n°4, was intoxicated for two weeks with the same daily amount of DOLIPRANE® and did not receive any treatment with pineapple. The rates of Alkaline Phosphatase (ALP), Glutamate Oxaloacetic Transaminase (GOT) and Glutamate Pyruvate Transaminase (GPT) enzymes were ganged. As for batch n°4, the values of those enzymes underwent a highly significant increase on the threshold of 0.1% when compared with the other three batches. ALP concentrations decreased from 406.67 ± 7.17 to 223.67 ± 3.28 for batch n°2 after the treatment with the pineapple. Concerning the GPT, value significantly decreased, passing from 242.67 ± 31.67 to 106 ± 2.31 for batch n° 2. As for the GOT, its rate passed from 184.67 ± 3.75 to 117.33 ± 2.73 for batch n°2, without any significance level on the threshold of 5%, comparing batches n° 2 and n°3. It emerges from this study that overdosing of DOLIPRANE® (2 g/kg of live weight) affected the biochemical level, the normal functioning of the liver of the wistar rats intoxicated per os. Fresh pineapple had a reconstructive effect on the hepatic metabolism of the intoxicated rats.

Key words: Liver detoxication, pineapple, dolipraneÒ, enzymes, wistar rats.