International Journal of Public Health and Epidemiology

International Journal of Public Health and Epidemiology ISSN 2326-7291 Vol. 10 (7), pp. 001-008, July, 2021. © International Scholars Journals

Full Length Research Paper

Chronic carriage of hepatitis B virus with HBeAg+ at the university teaching hospital YalgadoOuedraogo: epidemiological and clinical features

Eric Nagaonlé Somé1*, Alice Nanelin Guingané2**, Jean Kaboré1, Moussa Son2**, Félicité Nana1*, Maxime Drabo1* and Roger Sombié2**                                                                                                                                                     

1Institut de Recherche en Sciences de la Santé (IRSS), Biomedical and public health department, Ouagadougou, Burkina Faso.

2University Joseph Ki-Zerbo, UFR/SdS, gastro-enterology department, Ouagadougou, Burkina Faso.

Corresponding author E-mail: eric.some@gmail.com

Abstract

Accepted 05 March, 2021

Introduction: The prevalence of the hepatitis B infection is estimated at 9.1% in Burkina Faso. We aimed at describing the epidemiological and clinical features of the disease. Materials and methods: we implemented a cross-sectional study from January 1st, 2004 to December 31st, 2015. Patients aged more than 15 years with positive HBsAg for over six months and positive HbeAg were included. Results: We analyzed the data of 148 participants. The sex ratio was three; 69% of the participants were ≤34 years old. The mean duration of HBsAg carriage was 6.4 ± 5.6 years. The hepatic fibrosis blood test showed an activity ≥ 2 in 25 (83.3%) patients and fibrosis ≥ 2 in 23 (76.7%) patients. The liver biopsy found no inflammatory (A0) and a minimal activity (A1) in 25% and 62.5% of the patients, respectively. Portal fibrosis without (F1) and with some septa (F2) was found in three patients, respectively. Conclusion: Viral hepatitis B is a silent disease with a small proportion of patients experiencing viral replication activity. The control of this disease of public health interest is based mainly on programs of large immunization of the populations and a close monitoring of the infected people.

Key words: Viral hepatitis B, HBe antigen, HBs antigen, Sub Saharan Africa, Burkina Faso.