International Journal of Urology and Nephrology ISSN: 2091-1252 Vol. 3(3), pp. 082-089, March, 2015. © International Scholars Journals

Full Length Research Paper

Comparison of inflammation effects in the patients with familial mediterranean fever and dialysis patients

Nilgül Akalin, Md¹, Cemal Bes, Md², OzlemHarmankaya, Md¹, Kayhan Ertürk, Md³, Yıldız Okuturlar, Md⁴ and Baki Kumbasar, Md⁴

¹Bakirkoy Dr. SadiKonuk Training and Research Hospital Nephrology Unıt, Turkey.

²Bakirkoy Dr. SadiKonuk Training and Research Hospital Romatology Unıt, Turkey.

³İstanbul University Medical School Oncology Unıt, Turkey.

⁴ Bakirkoy Dr. SadiKonuk Training and Research Hospital İnternal Medicine Unıt, Turkey.

E-mail: nilnef@hotmail.com

Accepted 30 December, 2014

Abstract

We aimed to assess the presence and clinical effect of inflammation in the patients with familial mediterranean fever who follow-up treatment regularly. All the patients were measured with C-reactive proteine, homocysteine, fibrinogene levels and biochemical parameters; the presence of atherosclerotic plaque was investigated in the carotid intima artery. Leucocyte, C-reactive protein and fibrinogene levels were found to be significantly higher in the familial mediterranean fever group patients. Homocysteine levels and the presence of atherosclerotic plaque in the carotid intima artery were found to be significantly lower in the familial mediterranean fever group patients. Increasing the odds ratio for homocysteine was found to be related to dialysis treatments. The correlation between the presence of proteinuria, microalbuminuria, inflammation and the presence of atherosclerotic plaque in the carotid intima artery were not determinate to the familial mediterrian fever group of patients. We demonstrated that inflammation might be present continuously despite regular treatment in the patients with familial mediterrian fever and that this inflammation can be the main reasons or contributory factor to the complications of the disease. 

Key words:  Familial mediterrian fever, hemodialysis, ınflammation, peritoneal dialysis.