International Journal of Urology and Nephrology ISSN 2756-3855 Vol. 10 (2), pp. 001-007, February, 2022. © International Scholars Journals

Full Length Research Paper

Synthesis, antimicrobial potential and toxicological activities of Ni(II) complex of mefloquine hydrochloride

Joshua A. Obaleye², Johnson F. Adediji¹*, Ebenezer T. Olayinka¹ and Matthew A. Adebayo¹

¹Department of Chemical Sciences, Ajayi Crowther University Oyo, P. M. B 1066, Oyo, Oyo State, Nigeria.

²Department of Chemistry, University of Ilorin, Ilorin, Kwara State, Nigeria.

Accepted 24 September, 2021

Abstract

Transition metal complex of Ni(II) with mefloquine hydrochloride (antimalaria drug) was synthesized using a template method. Chemical analysis including conductivity measurements and spectroscopic studies were used to propose the geometry and mode of binding of the ligand to metal ion. From analytical data, the stoichiometry of the complex has been found to be 1:1. Infrared spectral data also suggest that the ligand (mefloquine hydrochloride) behaves as a tridentate ligand with N:N:O donor sequence towards the metal ion. The complex generally showed octahedral coordinate geometry. Molar conductance of 10^-2 mol dm^-3 methanol solution of the complex indicated non-electrolytic nature of metal complex. It also revealed that the ligand anions were covalently bonded to the complex. In vivo evaluation of antimalarial studies of the metal complex shows greater activities when compared to the free ligand. Mefloquine and its metal complex increased significantly (p < 0.05) serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) and significantly reduced these enzymes in the liver and kidney when compared to the control. This revealed that both mefloquine and its metal complex might show toxicity particularly on the liver and kidney with the metal complex group being mild.

Key words: Transition metal, antimicrobial, antimalarial drug, complexation, toxicological studies.