African Journal of Medicine and Surgery ISSN 3156-8734 Vol. 3 (3), pp. 069-073, March, 2016.  © International Scholars Journals

Full Length Research Paper

Use of MRI to monitor the location of gadolinium injections in normal humans

Justin Dion Lavigne1*, Rachel Candy2, Michael Michael3 and Norma Oscar4

1Automatic Subdermal Injection System, Inc, Westminster, California, Department of Otolaryngology/Head and Neck Surgery,

2Innovative Drug Injection Technology Inc., Newport Beach, California, Department of Anesthesiology, 3Magnolia Medical Imaging Centers, Westminster/Laguna Hills/Orange, California, Department of Radiology,

4University of California, Los Angeles, California, Department of Otolaryngology/Head and Neck Surgery


Accepted 7 February, 2016


Our previous study which monitored human muscular contractions with an accelerometer found out that the human muscles ran away from the electrical stimuli of an electromagnetic (EMG) needle. Thus, where the needle tip must likely end up every time is just outside of the fascia, or right in the subdermal bloodless space. The current study further explored the above hypothesis by using MRI to monitor the location of gadolinium injections. Using the initial prototype of the ASIS (Automatic Subdermal Injection System) device, gadolinium was successfully injected into the subdermal bloodless space in three out of three normal subjects’ glabellas. This innovation may have a major impact on the healthcare industry because bloodless injections imply longer-lasting medication, which will benefit most, if not all, injectable products.

Key words: Subdermal bloodless space, subdermal injection, injectable EMG needle, electrical stimulation, MRI with gadolinium, muscular contractions.