ISSN 2326-7291
International Journal of Public Health and Epidemiology ISSN 2326-7291 Vol. 11 (3), pp. 001-004, March, 2022. © International Scholars Journals
Full Length Research paper
Hepatoprotective and some haematological effects of Allium sativum and vitamin C in lead-exposed wistar rats
G. O. Ajayi1,2, T. T. Adeniyi1* and D. O. Babayemi1
1Department of Biochemistry, College of Natural Sciences, University of Agriculture, P. M. B. 2240, Abeokuta, Ogun State, Nigeria.
2Department of Medical Biochemistry, Faculty of Basic Medical Sciences, Lagos State University College of Medicine, P. M. B. 21266, Ikeja, Lagos, Nigeria.
Accepted 12 February, 2021
Abstract
The hepatoprotective and some haematological effects of Allium sativum (Garlic) and vitamin C were studied on experimental rats that were exposed to lead (Pb) for one week. Twenty – four female Wistar rats were divided into four groups of six rats per group. Rats in group A were kept as the control. Rats in groups B, C and D were exposed to 100 µmol/kg body weight of lead acetate intraperitoneally for seven days. Garlic diet (200 g minced garlic/kg diet) and vitamin C (500 mg/kg body weight) were given to rats in groups C and D for additional seven days respectively. Garlic and vitamin C produced significant reduction at p < 0.05 in the levels of ALT, ALP and PCV while the level of AST increases significantly at p < 0.05. The level of Hb increases significantly at p < 0.05 in rats treated with garlic and reduces significantly at p < 0.05 in rats treated with Vitamin C. This study, therefore suggests that garlic and vitamin C have some hepatoprotective and haematological effects.
Key words: Hepatoprotective, haematological, Allium sativum, vitamin C, Lead (Pb).