Advances in Agriculture and Agricultural Sciences

Advances in Agriculture and Agricultural Sciences ISSN 2756-326X Vol. 12 (2), pp. 001-005, February, 2026. Available online at www.internationalscholarsjournals.org © International Scholars Journals

Full Length Research Paper

In Vivo Evaluation of Anogeissus leiocarpus against Trypanosoma brucei brucei in Experimental Animals

A.U. Wurochekke* and G.O. Anyanwu

Biochemistry Department, Federal University of Technology, Yola

Accepted 5 November, 2025

Aqueous and methanol extracts of different parts of Anogeissus leiocarpus were analyzed for in vitro antitrypanosomal activity against Trypanosoma brucei brucei. The methanolic extract of the bark which had the highest in vitro activity against the parasite was selected for the in vivo analysis. Oral treatment with the methanolic bark extract to experimental rats at different doses (100,200mg/kg/day) for seven days did not clear the parasitemia. However, rats treated with 200 mg/kg/day survived longer than the infected control group. The results were discussed in respect to traditional treatment of trypanosomiasis.

Keywords: Anogeissus leiocarpus, Trypanosomiasis, Trypanosoma bruei brucei