ISSN 2326-7291
International Journal of Public Health and Epidemiology ISSN: 2167-0447 Vol. 3 (1), pp. 001-006, January, 2013. © International Scholars Journals
Full Length Research Paper
Frequency of the sickle cell disease and sickle cell trait in Heglig Area- Sudan
Malik Hassan Ibrahim Mustafa1,2, Elkhazin Ali Abd Elmageed Eltayeb2, Tariq Elfatih Elmisbah1,2 , Habab Merghani Yassin Babiker3 ,Nazar Abdelhafeez Osman Ali3 and Omaima Nasir1
1Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Turabah, Taif University , Kingdom of Saudi Arabia.
2Department of Hematology ,College of Medical Laboratory Sciences, Sudan University of Science and Technology, P. O. Box 407, Khartoum, Sudan.
3College of Medical Laboratory Sciences, Al-Nelain University, Khartoum, Sudan.
*Corresponding author. E-mail: [email protected].Tel. +96628224377, Fax: +96628221115
Accepted 18 July, 2013
Abstract
Sickle cell disease is a genetic, hereditary and chronic disease that affects the health of its carriers and might impair their health-related quality of life. The aim of the current study was to determine the sickle cell trait frequency in Sudanese patient living in Heglig area in Western of Southern Kordofan state from November 2008 to February 2009. An analytical, descriptive and cross-sectional study conducted for one hundred participants who had confirmed patient diagnosed as (Hb S disease) homozygosis patient,2-5 mL of venous blood was collected for the measurements of complete blood count, sickling test and Hb electrophoresis. Demographic data and family history were collected in a pre designed questionnaire with written consent all participants. In this study the frequency of sickle cell trait and sickle cell disease were (52%) and (14%) respectively and 34% were normal. The sickling test showed that 71 % of the study population were negative sickling test, the remaining 29 % were positive. The total erythrocytes was significantly decreased in sickle cell disease (p< 0.000) compared with normal and sickle cell trait, also the hemoglobin concentration and packed cell volume were significantly lower than that of normal individuals and sickle cell trait patients. The frequencies of sickle cell trait was higher among the participants and patients of sickle disease showed lower values of red blood cells parameters , but higher values of white blood cells and platelets compared to haemoglobin phenotype AA control participants.
Key words: Sickle cell disease, Frequencies, Haematological values, Heglig , Sudan.