ISSN 2167-0404
International Journal of Medicine and Medical Sciences
ISSN 2167-0404
Vol. 16, No. 1, January 2026
DOI: 10.14303/oajc.2010.001
pp. 1–8
Publisher: International Scholars Journals
Website: www.internationalscholarsjournals.org
Article Type: Original Research Article
Licensing: Subscription
Efficacy of Novel Beta-Blockers in Reducing Left Ventricular Hypertrophy: A Randomized Controlled Trial
Dr. Charles Vance, PhD¹; Dr. Elena Rostova, MD²
¹Department of Cardiovascular Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
²Division of Cardiology, Royal Brompton Hospital, London, UK
Manuscript Timeline:
Abstract
This study evaluated the clinical efficacy of early intravenous beta-blocker administration prior to primary percutaneous coronary intervention (PCI) in patients experiencing acute ST-segment elevation myocardial infarction (STEMI). A randomized, double-blind trial was conducted with 450 patients presenting within six hours of symptom onset. Participants were assigned to receive either early intravenous metoprolol or a matching placebo before undergoing PCI. The primary endpoint measured was the infarct size, assessed by cardiac magnetic resonance (CMR) imaging at day five, alongside the incidence of major adverse cardiovascular events (MACE) at 30 days. Results demonstrated a significant reduction in myocardial infarct size among patients in the early beta-blocker cohort compared to the placebo control group (p = 0.02). Furthermore, the 30-day MACE rate was significantly lower in the active treatment arm, driven primarily by a reduction in re-infarction and ventricular arrhythmias. Safety outcomes, including cardiogenic shock and symptomatic bradycardia, did not differ significantly between the two groups. Early administration of beta-blockers before primary PCI is safe and significantly reduces myocardial injury and short-term adverse events in STEMI patients.
Keywords: Acute Myocardial Infarction, Beta-Blockers, Percutaneous Coronary Intervention, Infarct Size, Ventricular Arrhythmias, ST-Segment Elevation.