ISSN 2167-0404
Research Article
International Journal of Medicine and Medical Sciences
ISSN 2167-0404
Vol. 16, No. 1, January 2026
DOI: 10.14303/oajc.2010.001
pp. 1–8
Publisher: International Scholars Journals
Website: www.internationalscholarsjournals.org
Article Type: Original Research Article
Licensing: Subscription
Efficacy of Novel Beta-Blockers in Reducing Left Ventricular Hypertrophy: A Randomized Controlled Trial
Dr. Charles Vance, PhD¹; Dr. Elena Rostova, MD²
¹Department of Cardiovascular Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
²Division of Cardiology, Royal Brompton Hospital, London, UK
Manuscript Timeline:
Abstract
This study evaluated the clinical efficacy of early intravenous beta-blocker administration prior to primary percutaneous coronary intervention (PCI) in patients experiencing acute ST-segment elevation myocardial infarction (STEMI). A randomized, double-blind trial was conducted with 450 patients presenting within six hours of symptom onset. Participants were assigned to receive either early intravenous metoprolol or a matching placebo before undergoing PCI. The primary endpoint measured was the infarct size, assessed by cardiac magnetic resonance (CMR) imaging at day five, alongside the incidence of major adverse cardiovascular events (MACE) at 30 days. Results demonstrated a significant reduction in myocardial infarct size among patients in the early beta-blocker cohort compared to the placebo control group (p = 0.02). Furthermore, the 30-day MACE rate was significantly lower in the active treatment arm, driven primarily by a reduction in re-infarction and ventricular arrhythmias. Safety outcomes, including cardiogenic shock and symptomatic bradycardia, did not differ significantly between the two groups. Early administration of beta-blockers before primary PCI is safe and significantly reduces myocardial injury and short-term adverse events in STEMI patients.
Keywords: Acute Myocardial Infarction, Beta-Blockers, Percutaneous Coronary Intervention, Infarct Size, Ventricular Arrhythmias, ST-Segment Elevation.
Charles Vance, Elena Rostova
Page: 1 - 8
Case Report
International Journal of Medicine and Medical Sciences ISSN 2167-0404 Vol. 11 (3), pp. 001-003, March, 2021. Available online at www.internationalscholarsjournals.org © International Scholars Journals
Case Report
Exploring a Unique Case of Uterine Leiomyosarcoma with Chronic Inversion: Insights and Implications
Rekha Sachan1*, Pooja Gupta1 and ML Patel2
1Department of Obstetrics and Gynaecology, CSM Medical University, Lucknow, India.
2Department of Medicine, CSM Medical University, Lucknow, India.
Accepted 22 October, 2020
Sarcomatous change in uterine fibroid is termed leiomyosarcoma. The tumor originates from smooth muscle cells and is rare, accounting for 2 to 5% of all uterine malignancies. The said patient had the history of irregular bleeding, but not typical menorrhagia, which is the usual presentation in this tumor. A 40 year old, P4+0 women of North Indian origin, was admitted with huge polypoidal fungating mass with bosselated surface and variegated mass protruding from introitus consistently. It was 12 ×10 cm in size with fundal cuping and cervical rim around the mass, which indicates inversion of the uterus. Total abdominal hysterectomy with bilateral salpingoophorectomy and bladder repair was done via abdomino-perineal route and the histopathology confirmed the diagnosis of leiomyosarcoma. Because of their rarity, uterine sarcomas are not recommended for routine screening. Surgery is the only treatment modality of leiomyosarcoma and prognosis depends upon the stage of the cancer.
Key words: Leiomyosarcoma, inversion, hysterectomy.
Rekha Sachan, Pooja Gupta, ML Patel
Page: 1 - 3
Research Article
International Journal of Medicine and Medical Sciences ISSN 2167-0404 Vol. 11 (2), pp. 001-004, February, 2021. Available online at www.internationalscholarsjournals.org © International Scholars Journals
Full Length Research Paper
From Procedure to Recovery: Understanding Quality of Life Changes After Septal Surgery
Mohammed Ayub Musani*, Itrat Javed, Yousuf Khambaty, Faheem Ahmed Khan and Syed Wadood Ul Hasnain
Department of ENT, Karachi Medical and Dental College, KARACHI, Pakistan.
Accepted 30 November, 2020
Abstract
To assess the quality of life in patients who have been through the surgical intervention related to nasal septum in ENT department of Abbasi Shaheed Hospital, Karachi. This study was done from January 2008 to August 2008. Case based study, with post-interventional quality of life assessment questionnaire. One hundred patients undergoing nasal septum related surgery, after their full informed and written consent, were included in this study. The age limit was above 18 years and both the sexes were included. They were given a questionnaire (Glasgow benefit inventory score-GBI) to be fulfilled on the first follow up day after a week’s time from the day of surgery and then subsequently on the second visit that is, at about two week’s time from their first visit and the last one after the lapse of 1 month from the time of second visit. Average score of patients as per the GBI on the first follow up visit was 17; on second subsequent visit was 39 and on the last visit it was 50 thereby showing a positive correlation between the improvement in quality of life and septal surgery. Septal surgery has a definite and positive impact on improving the health related quality of life of patients.
Key words: Quality of life (QOL) after surgery, outcome assessments.
Mohammed Ayub Musani, Itrat Javed, Yousuf Khambaty, Faheem Ahmed Khan, Syed Wadood Ul Hasnain
Page: 1 - 4
Case Report
International Journal of Medicine and Medical Sciences ISSN 2167-0404 Vol. 11 (1), pp. 001-005, January, 2021. Available online at www.internationalscholarsjournals.org © International Scholars Journals
Case Report
Neonatal Immature Gastric Teratoma: Pathophysiology and Treatment Outcomes
Ahmed H. Al-Salem
Department of Pediatric Surgery, Maternity and Children Hospital, Dammam, Saudi Arabia.
E-mail: [email protected].
Accepted 25 October, 2020
Gastric teratomas are very rare embryonal neoplasms and accounts for less than 1% of all teratomas occurring in infants and children. It is usually seen in male infants who present with upper abdominal mass and commonly it is benign. This report describes a large immature grade II gastric teratoma in a male newborn. The tumor was treated with total excision including part of the stomach.
Key words: Gastric teratoma, newborn, immature.
Ahmed H. Al-Salem
Page: 1 - 5
Research Article
International Journal of Medicine and Medical Sciences ISSN 2167-0404 Vol. 10 (8), pp. 001-008, August, 2020. © International Scholars Journals
Full Length Research Paper
A comparative study on the atheroprotective potential of heparin and atorvastatin in hypercholesterolemic rats
Vijayabaskar, P.1, Sethupathy, S.2 and Somasundaram, S. T.1*
1Centre of Advanced Study in Marine Biology, Annamalai University, Parangipettai –608 502, Tamilnadu, India.
2Division of Biochemistry, Rajah Muthiah Medical College and Hospital, Annamalai University, Annamalai nagar -608 002, Tamilnadu, India.
Accepted 01 May, 2020
Abstract
The present study is to evaluate the effect of standard drug heparin and atorvastatin on the atherogenic disturbances in hypercholesterolemic atherogenic animals. Six groups of male Wistar rats were employed in this study, of which three groups received atherogenic CCT diet (rat chow supplemented with 4% cholesterol, 1% cholic acid and 0.5% thiouracil) for 17 days. Two groups were treated with standard heparin (200 units/kg/day, s.c) and atorvastatin (1.34 mg/kg/day, oral gavage) respectively commencing from 10th day of the experimental period with the remaining group served as control. Another 3 groups received normal rat chow diet during the entire experimental period. One group received only CCT diet while the other two groups received heparin and atorvastatin respectively. Increase in the plasma levels of cholesterol, triglycerides, high density lipoprotein, very low density lipoprotein and low density lipoprotein induced by CCT diets were normalized by heparin and statin treatment. The CCT diet induced abnormal rise with the plasma hepatic marker enzymes alkaline phosphatase, alanine transaminases and aspartate transaminases, plasma urea, glucose and creatinine levels were restored to normal with the treated groups. The CCT diet induced lecithin cholesterol acyltransferase (LCAT) and lipoprotein lipase (LPL) activities were restored to normal in the treated groups. Standard heparin and atorvastatin intervention minimized the atherogenic diet induced histopathological lesions in liver, kidney and aortic tissues.
Key words: CCT diet, Atherosclerosis, standard heparin, atorvastatin, LCAT, LPL.
Vijayabaskar , P. , Sethupathy , S. and Somasundaram, S. T.*
Page: 1 - 8
Research Article
International Journal of Medicine and Medical Sciences ISSN 2167-0404 Vol. 10 (8), pp. 001-009, August, 2020. © International Scholars Journals
Full Length Research Paper
Effect of aerobic pre-treatment on production of hydrolases and volatile fatty acids during anaerobic digestion of solid sisal leaf decortications residues
Anthony Manoni Mshandete1*, Lovisa Björnsson2, Amelia Kajumulo Kivaisi1, Mugassa Steven Thomas Rubindamayugi1 and Bo Mattiasson2
1Department of Molecular Biology and Biotechnology, University of Dares, Salaam. P.O. Box 35179, Dares Salaam. Tanzania.
2Department of Biotechnology, Centre for Chemistry and Chemical Engineering, Lund University, P.O. Box 124, SE-22100, Lund, Sweden.
Accepted 22 July, 2020
Abstract
The effect of aerobic pretreatment on the production of hydrolases and volatile fatty acids during anaerobic digestion of solid sisal decortications leaf residue (SLDR) was investigated. Batch solid waste bioreactors with working volume of 2 litres were used in this study. Batch loads of aerobically treated or untreated sisal leaf residue inoculated with activated sludge mixed culture were packed into the bioreactors and operated anaerobically for 400 h. The fermentation products were mainly (mg/g total volatile fatty acids, VFAs): acetic acid (287), n-butyric acid (201), n-valeric acid (96) and caproic acid (62) as well as with low amounts of propionic acid and iso-butyric acid for aerobic pre-treated sisal leaf waste solids. Contrarily, for the untreated system, the fermentation products were chiefly (mg/g total volatile fatty acids): propionic acid (317), iso-butyric acid (276), n-butyric acid (96), acetic acid (84) and insignificant amounts of n-valeric acid, iso-valeric acid and caproic acid. Although the activities of hydrolytic enzymes found were similar for both treated and untreated SLDR, proportions of VFAs obtained with the former residues appeared to be better substrates for biomethanantion than those obtained from the latter substrates. These results indicated the potential of aerobic pre- treatment for enhanced bioconversion of SLDR. The present study, reports for the first time the types and levels of VFAs and hydrolases produced during anaerobic digestion of aerobic pre-treated SLDR and could be used as a basis for designing a pilot scale process.
Key words: Aerobic pre-treatment, hydrolases, volatile fatty acids, anaerobic digestion, sisal leaf decortications residues.
Lovisa Björnsson, Amelia Kajumulo Kivaisi, Mugassa Steven Thomas Rubindamayugi and Bo Mattiasson, Anthony Manoni Mshandete*
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