ISSN 2756-3375
African Journal of Immunology Research ISSN 9431-5833 Vol. 5 (5), pp. 346-348, May, 2018. © International Scholars Journals
Short Communication
Clinical, laboratory aspects and therapy response of patients with a rare complication of the EBV infection
Mehmet Akın*, Özlem ẞahin, Kazim Küçükta ci, Burçin Kaya, Ersin Gozkeser, Murat Çağlar and Firat Erdoğan
Department of Pediatric Hematology, Faculty of Medicine, Pamukkale University,
Denizli, Turkey.
*Corresponding author. E-mail: [email protected]. Tel: +90 505 3945276.
Accepted 06 July, 2016
Abstract
Primary Epstein-Barr virus infection in children is usually asymptomatic, but some children or young adults manifest infectious mononucleosis with typical symptoms of fever, pharyngitis, lymphadenopathy, hepatosplenomegaly and a typical lymphocytosis. The infection caused by Epstein-Barr Virus (EBV) can be followed by immunological complications. One of these is autoimmune hemolytic anemia (AIHA) that it is rare but well known ~1:1000 patients with infectious mononucleosis. Two male patients, aged 2 and 2.5 years old with autoimmune hemolytic anemia caused by Epstein-Barr virus admitted to our hospital with pallor, palpitation, fever and scleral icterus. Viral capsid antigen -IgM was positive in both cases, indicating the presence of primary Epstein-Barr virus infection. AIHA risk of EBV infection in the first two weeks might be considered closely because of life threatining complications such as autoimmune hemolytic anemia.
Key words: Epstein-Barr Virus, coombs positive, autoimmune hemolytic anemia.