International Journal of Medicinal Plants Research

International Journal of Medicinal Plants Research ISSN 2169-303X Vol. 8 (1), pp. 001-009, January, 2019. © International Scholars Journals

Full Length Research Paper

Phytochemical and biological investigation of Tanacetum parthenium (L.) cultivated in Egypt

Mostafa E. M. Rateb¹, Abdel-Nasser A. M. El-Gendy², Seham S. El-Hawary³ and Ali M. El-Shamy³

¹Pharmacognosy Department, Faculty of Pharmacy, Beni-Sueif University, Egypt.

²Pharmacology Department, Faculty of Veterinary Medicine, Beni-Sueif University, Egypt.

³Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Egypt.

Accepted 17 October, 2018

Abstract

Phytochemical investigation of Tanacetum parthenium (L.) family Asteraceae cultivated in Egypt resul-ted in isolation and identification of four flavonoids isolated from the aerial part, four sesquiterpene lactones isolated from the leaves, two sterols isolated from the roots. A comparative study of the essential oil content of the leaves and the flower heads was performed using (GC/MS) revealing the presence of 42 and 30 components with the major components camphor (constituted 37.7 and 48.4%) and chrysanthenyl acetate (constituted 33.8 and 26.3%) in the leaves and the flower heads, respectively. Different extracts of T. parthenium (L.) showed significant analgesic, anti-inflammatory, antipyretic, antispasmodic and uterine-stimulant activities in addition to the in vitro cytotoxic effect.

Key words: Tanacetum parthenium, ethanol and water extracts, essential oil, analgesic, anti-inflammatory, antipyretic, antispasmodic, uterine stimulant and cytotoxic.

International Journal of Medicinal Plants Research ISSN 2169-303X Vol. 8 (1), pp. 001-004, January, 2019. © International Scholars Journals

Full Length Research Paper

Use of Jatropha gossypifolia stem latex as a haemostatic agent: how safe is it?

T. Oduola^1*, G. B. Popoola¹, O. G. Avwioro², T. A. Oduola³, A.A. Ademosun¹ and M. O. Lawal¹

¹Department of Haematology, Special Investigations Laboratory, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Nigeria.

²Department of Histopathology, School of Medical Laboratory Science, Obafemi Awolowo University Teaching Hospital Complex Ile-Ife, Nigeria

³Department of Medicine, Obafemi Awolowo University Teaching Hospital Complex, Ile-Ife, Nigeria.

Accepted 22 October, 2018

Abstract

The stem latex of Jatropha grossypifolia is routinely used by local and some urban dwellers in Southern Nigeria to stop bleeding from nose, gum and injured skin. Safety of its use was investigated in different groups of wistar albino rats using different doses of the latex. Different numbers of incisions were made on the thighs of different groups of animals and different doses of the stem latex applied. The procedure was repeated on daily basis for 18 days. The control group was not incised. The animals were sacrificed and the effect of the stem latex on blood biochemistry and haematology were assessed using standard techniques. There were no statistical significant differences (P>0.05) in the result of biochemical and haematological parameters obtained for the control and experimental animals. The findings of this study showed that the stem latex of Jatropha gossypifolia has no harmful effects.

Key words: Safety, Jatropha gosssypifolia, stem latex, biochemical, haematological, parameters.

International Journal of Medicinal Plants Research ISSN 2169-303X Vol. 7 (12), pp. 001-004, December, 2018. © International Scholars Journals

Full Length Research Paper

Toxicity studies on an unripe Carica papaya aqueous extract: Biochemical and haematological effects in wistar albino rats

Oduola, T^1*, Adeniyi F. A. A.², Ogunyemi E. O.³, Bello, I. S.⁴, Idowu T. O⁵ and Subair, H.G⁶

¹Department of Haematology, Special Investigations Laboratory, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Nigeria.

²Department of Chemical Pathology, University of Ibadan, Ibadan, Nigeria.

³Department of Chemical Pathology, Olabisi Onabanjo University, Ago-Iwoye, Nigeria.

⁴Department of General Medical Practice, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Nigeria.

⁵Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife. Nigeria.

⁶Department of Pharmacology, Drug Research and Production unit, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife, Nigeria.

Accepted 09 September, 2018

Abstract

Aqueous extract of unripe Carica papaya is consumed by some sickle cell patients for its antisickling activities in some parts of southern Nigeria without considering its safety. The effects of the extract on functions of the liver, kidney and bone marrow were investigated in 30 wistar albino rats. The rats were in 6 groups of 5 animals per group. The first group is the control and the other five groups were the study groups. The oral acute toxicity of the extract (LD₅₀) was determined, different doses, 50, 100, 150, 200 and 250 mg/kg were administered daily to the study groups (A, B, C, D, E) respectively for 6 weeks. Liver, kidney and bone marrow function tests were assessed using standard techniques. The results obtained for biochemical and haematological parameters for the control and experimental groups showed no statistical significant different (P>0.05). This result showed that the intake of unripe C. papaya extract had no adverse effects on the functions of these organs in rats.

Key words: Carica papaya, aqueous extract, liver, kidney, bone marrow, antisickling.

International Journal of Medicinal Plants Research ISSN 2169-303X Vol. 7 (12), pp. 001-006, December, 2018. © International Scholars Journals

Full Length Research paper

Clinical effect of chronic osteomyelitis treated by integrated Chinese-Western therapy

Chang Qi*, Huang Tao and Huang Changlin

Military Training Medicine Institute in the 150th Hospital of PLA, Luoyang, Henan province, China.

Accepted 12 October, 2018

Abstract

Both Western and Chinese medicine have their own advantages in treating chronic osteomyelitis. In this study, we investigated the methods and clinical effect of chronic osteomyelitis treated by integrated Chinese-Western therapy. This is a prospective study. A total of 121 cases of chronic osteomyelitis (treated in the Military Training Medicine Institute hospital from January, 2002 to February, 2010) were divided into three groups, respectively treated with methods of traditional Chinese medicine, methods of Western medicine and integrated Chinese-Western therapy. All the patients were followed up and ranged from 8 to 56 months, with an average of 30 months. The total effective rate of the cases treated with methods of traditional Chinese medicine was 66.7%, cases treated with methods of western medicine was 54.8%, cases treated with integrated Chinese-Western therapy was 88.9%; the average period of hospitalization of cases treated with methods of traditional Chinese medicine was 59.3 days, cases treated with methods of western medicine was 74.6 days, cases treated with integrated Chinese-Western therapy was 43.7 days. There was a significant difference between the first two groups and the last one in terms of effective rate and average period of hospitalization. It is conspicuously effective to treat chronic osteomyelitis with integrated Chinese-Western therapy, which proved to be more powerful in improving recovery rate and reducing period of hospitalization than pure methods of traditional Chinese medicine or pure methods of Western medicine.

Key words: Chronic osteomyelitis, integrated Chinese-Western therapy.

International Journal of Medicinal Plants Research ISSN 2169-303X Vol. 7 (12), pp. 001-007, December, 2018. © International Scholars Journals

Full Length Research paper

Prevalence of crude drugs used in Arab folk medicine available in Makkah Al-Mukarramah Area

Amal Abdulaziz Bajrai

Obesity Centre, College of Medicine, King Saud University, P. O. Box 2925. Riyadh, Saudi Arabia. E-mail: [email protected], [email protected]. Tel: +966 14677338, +966 505505864. Fax: +966 1291444.

Accepted 21 June, 2018

Abstract

This article is based on the results of a preliminary ethno-botanical research survey conducted in Makkah Al-Mukarramah area. The main objective of this paper was to enlist the wealth of crude drugs (botanical medicinal materials) available in the Attar shops (herbal drug stores) along with their folkloric uses. A total of 71 species, belonging to 40 families and 69 genera were enlisted and their therapeutic uses were also described.

Key words: Crude drugs, prevalence, survey, Makkah.

International Journal of Medicinal Plants Research ISSN 2169-303X Vol. 7 (11), pp. 001-005, November, 2018. © International Scholars Journals

Full Length Research Paper

Ethnozoological study of traditional medicinal animals used by the people of Kafta-Humera District, Northern Ethiopia

Gidey Yirga*, Mekonen Teferi and Yemane Gebreslassea

Department of Biology, Mekelle University, P. O. Box 3072, Mekelle, Ethiopia.

Accepted 06 September, 2018

Abstract

Zootherapy is the healing of human ailments by using therapeutics based medicines obtained from animals. The present study reports the use of drugs of animal origin that have been practiced by the people of Kunama in Kafta-Humera district, Northern Ethiopia. Ethnozoological data was collected from 30 traditional healers who were selected based on their experience and recognition as experts from September to November, 2010. Sixteen species of medicinal animals were collected and identified for treating 18 different human ailments, of which about 44% were domestic animals. The traditional medicine were administrated orally (14, 63.6%) and dermatologically (8, 36.4%). Majority (17, 77.3%) of the remedy preparations did not have additive substances. Different parts and products of animals that were used for remedy preparations include bile, milk, blood, pancreas, urine, hair and fecal matter. The medicinal animals have various methods of preparation for different types of ailments like crushing, powdering, squeezing, direct use and cooking. Most of the traditional medicinal animal preparations were used in fresh form (16, 72.7%). Further studies concerning the conservation and management of the animal resources are needed. People of the study area should take care of their animal resources so as not cause total eradication.

Key words: Ethnozoolgy, Kafta Humera, medicinal animals.